InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACR1

Summary

InnateDB Protein

IDBP-295463.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACR1

Protein Name

tachykinin receptor 1

Synonyms

NK1R; NKIR; SPR; TAC1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000386448

InnateDB Gene

IDBG-58132 (TACR1)

Protein Structure

UniProt Annotation

Function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0009582	detection of abiotic stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000046 Neurokinin NK1 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001681 Neurokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR01024
PR00237
PR01012
PR00244

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25103