InnateDB Protein
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IDBP-295464.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DERL1
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Protein Name
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Der1-like domain family, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384289
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InnateDB Gene
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IDBG-34429 (DERL1)
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Protein Structure
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Function |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856, ECO:0000269PubMed:16186509, ECO:0000269PubMed:16449189}; Multi- pass membrane protein {ECO:0000269PubMed:15215855, ECO:0000269PubMed:15215856, ECO:0000269PubMed:16186509, ECO:0000269PubMed:16449189}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:15215855, ECO:0000269PubMed:16449189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
58
[view]
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Protein-Protein |
57
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006986
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response to unfolded protein
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GO:0019060
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intracellular transport of viral protein in host cell
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0030970
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retrograde protein transport, ER to cytosol
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GO:0045184
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establishment of protein localization
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Cellular Component |
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PDB ID |
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InterPro |
IPR007599
Derlin
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PFAM |
PF04511
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUN8
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PhosphoSite |
PhosphoSite-Q9BUN8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79139
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UniGene |
Hs.597382
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RefSeq |
NP_001128143
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HUGO |
HGNC:28454
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OMIM |
608813
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CCDS |
CCDS47915
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HPRD |
12302
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IMGT |
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EMBL |
AC104316
AK124086
AY358818
BC002457
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GenPept |
AAH02457
AAQ89177
BAG54003
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