Homo sapiens Protein: LPAR2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-295467.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | LPAR2 | ||||||||||||||||||
Protein Name | lysophosphatidic acid receptor 2 | ||||||||||||||||||
Synonyms | EDG-4; EDG4; LPA-2; LPA2; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000384665 | ||||||||||||||||||
InnateDB Gene | IDBG-40085 (LPAR2) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269PubMed:15143197, ECO:0000269PubMed:19306925}. | ||||||||||||||||||
Subcellular Localization | Cell surface {ECO:0000269PubMed:19306925}. Cell membrane {ECO:0000269PubMed:19306925}; Multi-pass membrane protein {ECO:0000269PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR001671 Melanocortin/ACTH receptor IPR002277 Lysophosphatidic acid receptor EDG-2 IPR004061 Sphingosine 1-phosphate receptor IPR004065 Lysophosphatidic acid receptor IPR004066 Lysophosphatidic acid receptor EDG-4 IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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PFAM |
PF00001
PF10320 |
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PRINTS |
PR00237
PR00534 PR01148 PR01523 PR01527 PR01528 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9HBW0 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9HBW0 | ||||||||||||||||||
TrEMBL | K7ER68 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9170 | ||||||||||||||||||
UniGene | Hs.585897 | ||||||||||||||||||
RefSeq | NP_004711 | ||||||||||||||||||
HUGO | HGNC:3168 | ||||||||||||||||||
OMIM | 605110 | ||||||||||||||||||
CCDS | CCDS12407 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC002306 AC011458 AF011466 AF197929 AF233092 AY322548 BC025695 CH471106 | ||||||||||||||||||
GenPept | AAB61528 AAC27728 AAF43409 AAG28521 AAH25695 AAP84361 EAW84836 EAW84837 | ||||||||||||||||||