Homo sapiens Gene: LPAR2
Summary
InnateDB Gene IDBG-40085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPAR2
Gene Name lysophosphatidic acid receptor 2
Synonyms EDG-4; EDG4; LPA-2; LPA2
Species Homo sapiens
Ensembl Gene ENSG00000064547
Encoded Proteins
lysophosphatidic acid receptor 2
lysophosphatidic acid receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19623668-19628930
Strand Reverse strand
Band p13.11
Transcripts
ENST00000407877 ENSP00000384665
ENST00000542587 ENSP00000443256
ENST00000588233 ENSP00000466112
ENST00000590629
ENST00000592061 ENSP00000465206
ENST00000588461 ENSP00000466940
ENST00000591042 ENSP00000468132
ENST00000589311
ENST00000586703 ENSP00000465280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0030165 PDZ domain binding
GO:0070915 lysophosphatidic acid receptor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0035025 positive regulation of Rho protein signal transduction
GO:0043410 positive regulation of MAPK cascade
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (i) signalling events pathway
Lysosphingolipid and LPA receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
LPA receptor mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.122575 Hs.585897
RefSeq NM_004720
HUGO
OMIM
CCDS CCDS12407
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas