InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOK1

Summary

InnateDB Protein

IDBP-295470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOK1

Protein Name

docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Synonyms

P62DOK;

Species

Homo sapiens

Ensembl Protein

ENSP00000387016

InnateDB Gene

IDBG-57879 (DOK1)

Protein Structure

UniProt Annotation

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269PubMed:18156175}.

Subcellular Localization

Isoform 1: Cytoplasm. Nucleus.Isoform 3: Cytoplasm, perinuclear region.

Disease Associations

Tissue Specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269PubMed:12595900}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008286	insulin receptor signaling pathway