Version 5.4
Homo sapiens Gene: DOK1
Summary
InnateDB Gene IDBG-57879.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK1
Gene Name docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Synonyms P62DOK
Species Homo sapiens
Ensembl Gene ENSG00000115325
Encoded Proteins
IDBP-57881
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
IDBP-57883
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
IDBP-295470
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
IDBP-380962
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74549026-74557554
Strand Forward strand
Band p13.1
Transcripts
ENST00000233668 ENSP00000233668
ENST00000340004 ENSP00000344330
ENST00000409429 ENSP00000387016
ENST00000429631 ENSP00000393586
ENST00000485132
ENST00000488613
ENST00000489958
ENST00000482206
ENST00000474924
ENST00000480318
ENST00000496966
ENST00000475191
ENST00000464613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068335
View Gene Order
ENSBTAG00000018579
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_15
IL3 pathway
REACTOME
REACT_508
Signal attenuation pathway
REACT_570
IRS activation pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
KEGG
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
ret_pathway
Signaling events regulated by Ret tyrosine kinase
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
pdgfrbpathway
PDGFR-beta signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.103854 Hs.691152
RefSeq NM_001197260 NM_001381 XM_006711959
HUGO
OMIM
CCDS CCDS1954 CCDS56125
HPRD 04228
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca