InnateDB Protein
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IDBP-295619.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ADD2
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Protein Name
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adducin 2 (beta)
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Synonyms
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ADDB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384303
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InnateDB Gene
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IDBG-55426 (ADD2)
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Protein Structure
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Function |
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269PubMed:18347014}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. {ECO:0000269PubMed:12951058}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001303
Class II aldolase/adducin N-terminal
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PFAM |
PF00596
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PRINTS |
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PIRSF |
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SMART |
SM01007
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TIGRFAMs |
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Modification |
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SwissProt |
P35612
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PhosphoSite |
PhosphoSite-P35612
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TrEMBL |
Q96HD4
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UniProt Splice Variant |
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Entrez Gene |
119
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UniGene |
Hs.188528
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RefSeq |
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HUGO |
HGNC:244
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OMIM |
102681
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CCDS |
CCDS1906
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HPRD |
00037
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IMGT |
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EMBL |
AB209227
AB593080
AC005234
AC007395
AF486420
AF486421
AF486422
AF486423
AK291007
AK297250
AK309773
BC008709
BC041666
BC051882
BC056881
BC065525
CH471053
S81077
S81079
U43959
X58199
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GenPept |
AAA86421
AAD12715
AAD14349
AAH08709
AAH41666
AAH51882
AAH56881
AAH65525
AAP71863
AAP71864
AAP71865
AAP71866
BAD92464
BAF83696
BAG59729
BAJ84020
CAA41176
EAW99801
EAW99806
EAW99807
EAW99808
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