Version 5.4
Homo sapiens Gene: ADD2
Summary
InnateDB Gene IDBG-55426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADD2
Gene Name adducin 2 (beta)
Synonyms ADDB
Species Homo sapiens
Ensembl Gene ENSG00000075340
Encoded Proteins
IDBP-55428
adducin 2 (beta)
IDBP-55430
adducin 2 (beta)
IDBP-295620
adducin 2 (beta)
IDBP-295619
adducin 2 (beta)
IDBP-378783
adducin 2 (beta)
IDBP-378787
adducin 2 (beta)
IDBP-378792
adducin 2 (beta)
IDBP-378793
adducin 2 (beta)
IDBP-378794
adducin 2 (beta)
IDBP-378797
adducin 2 (beta)
IDBP-482423
adducin 2 (beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70607618-70768225
Strand Reverse strand
Band p13.3
Transcripts
ENST00000355733 ENSP00000347972
ENST00000264436 ENSP00000264436
ENST00000407644 ENSP00000384677
ENST00000403045 ENSP00000384303
ENST00000456320 ENSP00000414546
ENST00000413157 ENSP00000388072
ENST00000430656 ENSP00000398112
ENST00000415348 ENSP00000412357
ENST00000425976 ENSP00000412681
ENST00000447731 ENSP00000403722
ENST00000481675
ENST00000522886 ENSP00000430243
ENST00000473232
ENST00000496178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005516 calmodulin binding
GO:0030507 spectrin binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0030036 actin cytoskeleton organization
GO:0030097 hemopoiesis
GO:0032092 positive regulation of protein binding
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0008290 F-actin capping protein complex
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030000
View Gene Order
ENSBTAG00000009076
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.188528
RefSeq NM_001185054 NM_001185055 NM_001617 NM_017482 NM_017488
HUGO
OMIM
CCDS CCDS1906 CCDS1909 CCDS46318 CCDS54365
HPRD 00037
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca