Version 5.4
Homo sapiens Protein: ANO7
Summary
InnateDB Protein IDBP-295650.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO7
Protein Name anoctamin 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385418
InnateDB Gene IDBG-85069 (ANO7)
Protein Structure
UniProt Annotation
Function Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. {ECO:0000269PubMed:17308099}.
Subcellular Localization Isoform 1: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell-cell contact. Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604.Isoform 2: Cytoplasm, cytosol.
Disease Associations
Tissue Specificity Specifically expressed in epithelial cells of the prostate (at protein level). {ECO:0000269PubMed:14981236, ECO:0000269PubMed:15761874, ECO:0000269PubMed:17308099}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IWH7
PhosphoSite PhosphoSite-Q6IWH7
TrEMBL Q8N348
UniProt Splice Variant
Entrez Gene 50636
UniGene Hs.163909
RefSeq
HUGO HGNC:31677
OMIM 605096
CCDS
HPRD 16090
IMGT
EMBL AC005237 AC104841 AC111201 AY617079 AY617080 BC028162
GenPept AAH28162 AAT40139 AAT40140

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca