Version 5.4
Homo sapiens Protein: C1D
Summary
InnateDB Protein IDBP-295726.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1D
Protein Name C1D nuclear receptor corepressor
Synonyms hC1D; LRP1; SUN-CoR; SUNCOR;
Species Homo sapiens
Ensembl Protein ENSP00000386779
InnateDB Gene IDBG-54438 (C1D)
Protein Structure
UniProt Annotation
Function Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization.
Disease Associations
Tissue Specificity Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. {ECO:0000269PubMed:10362552}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007146 Sas10/Utp3/C1D
PFAM PF04000
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13901
PhosphoSite PhosphoSite-Q13901
TrEMBL
UniProt Splice Variant
Entrez Gene 10438
UniGene Hs.602900
RefSeq NP_001177194
HUGO HGNC:29911
OMIM 606997
CCDS CCDS1883
HPRD 07382
IMGT
EMBL AC079112 AK290451 BC005235 BC009584 BC009589 BC016284 CH471053 X95592
GenPept AAH05235 AAH09584 AAH09589 AAH16284 AAX88887 BAF83140 CAA64845 EAW99884 EAW99885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca