InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIMD1

Summary

InnateDB Protein

IDBP-29605.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMD1

Protein Name

LIM domains containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000273317

InnateDB Gene

IDBG-29603 (LIMD1)

Protein Structure

UniProt Annotation

Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269PubMed:15542589, ECO:0000269PubMed:20303269, ECO:0000269PubMed:20616046, ECO:0000269PubMed:21834987, ECO:0000269PubMed:22286099}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down- regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.

Disease Associations

Tissue Specificity

Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. {ECO:0000269PubMed:10647888, ECO:0000269PubMed:18712738}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0002076	osteoblast development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008360	regulation of cell shape
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0035195	gene silencing by miRNA
GO:0035331	negative regulation of hippo signaling
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000637	positive regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0016442	RISC complex