InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MESP2

Summary

InnateDB Protein

IDBP-29611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MESP2

Protein Name

mesoderm posterior 2 homolog (mouse)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342392

InnateDB Gene

IDBG-29609 (MESP2)

Protein Structure

UniProt Annotation

Function

Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Spondylocostal dysostosis 2, autosomal recessive (SCDO2) [MIM:608681]: A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf- like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. {ECO:0000269PubMed:15122512}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001756	somitogenesis
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0008078	mesodermal cell migration
GO:0023019	signal transduction involved in regulation of gene expression
GO:0032525	somite rostral/caudal axis specification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter