Homo sapiens Gene: MESP2

Summary
InnateDB Gene IDBG-29609.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol MESP2
Gene Name mesoderm posterior 2 homolog (mouse)
Synonyms bHLHc6; SCDO2
Species Homo sapiens
Ensembl Gene ENSG00000188095
Encoded Proteins
IDBP-29611 mesoderm posterior 2 homolog (mouse)
IDBP-602957 mesoderm posterior 2 homolog (mouse)
Entrez Gene
Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 90303822-90321982
Strand Forward strand
Band q26.1
Transcripts
ENST00000341735  ENSP00000342392
ENST00000560219  ENSP00000452998
ENST00000558723 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-dependent
GO:0007219 Notch signaling pathway
GO:0008078 mesodermal cell migration
GO:0023019 signal transduction involved in regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000030543 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q0VG99 
TrEMBL H0YKZ5
UniProt Splice Variant
Entrez Gene 145873 
UniGene Hs.37311
RefSeq NM_001039958 
HUGO 29659 
OMIM 605195
CCDS CCDS42078 
HPRD
IMGT
EMBL AC079075 BC111413 BK000142
GenPept AAI11414  DAA00304 
ImmGen MESP2 (murine) 
RNA Seq Atlas 145873