Homo sapiens Gene: MESP2
Summary
InnateDB Gene IDBG-29609.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol MESP2
Gene Name mesoderm posterior 2 homolog (mouse)
Synonyms bHLHc6; SCDO2;
Species Homo sapiens
Ensembl Gene ENSG00000188095
Encoded Proteins
mesoderm posterior 2 homolog (mouse)
mesoderm posterior 2 homolog (mouse)
Protein Structure
Entrez Gene
Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90303822-90321982
Strand Forward strand
Band q26.1
Transcripts
ENST00000341735 ENSP00000342392
ENST00000560219 ENSP00000452998
ENST00000558723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-dependent
GO:0007219 Notch signaling pathway
GO:0008078 mesodermal cell migration
GO:0023019 signal transduction involved in regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q0VG99
TrEMBL H0YKZ5
UniProt Splice Variant
Entrez Gene 145873
UniGene Hs.37311
RefSeq NM_001039958
HUGO 29659
OMIM 605195
CCDS CCDS42078
HPRD
IMGT
EMBL AC079075 BC111413 BK000142
GenPept AAI11414 DAA00304
ImmGen MESP2 (murine)
RNA Seq Atlas 145873