InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP3A5

Summary

InnateDB Protein

IDBP-29634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP3A5

Protein Name

cytochrome P450, family 3, subfamily A, polypeptide 5

Synonyms

CP35; CYPIIIA5; P450PCN3; PCN3;

Species

Homo sapiens

Ensembl Protein

ENSP00000222982

InnateDB Gene

IDBG-29632 (CYP3A5)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0009822	alkaloid catabolic process
GO:0010628	positive regulation of gene expression
GO:0042737	drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV
IPR008072 Cytochrome P450, E-class, CYP3A

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00464
PR00465
PR01689

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20815