Version 5.4
Homo sapiens Gene: CYP3A5
Summary
InnateDB Gene IDBG-29632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP3A5
Gene Name cytochrome P450, family 3, subfamily A, polypeptide 5
Synonyms CP35; CYPIIIA5; P450PCN3; PCN3
Species Homo sapiens
Ensembl Gene ENSG00000106258
Encoded Proteins
IDBP-29634
cytochrome P450, family 3, subfamily A, polypeptide 5
IDBP-29805
cytochrome P450, family 3, subfamily A, polypeptide 5
IDBP-383004
cytochrome P450, family 3, subfamily A, polypeptide 5
IDBP-383006
cytochrome P450, family 3, subfamily A, polypeptide 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2010]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99648194-99679998
Strand Reverse strand
Band q22.1
Transcripts
ENST00000222982 ENSP00000222982
ENST00000339843 ENSP00000343074
ENST00000439761 ENSP00000401269
ENST00000456417 ENSP00000415399
ENST00000469887
ENST00000461920
ENST00000488187
ENST00000473347
ENST00000463364
ENST00000481825
ENST00000466061
ENST00000480723
ENST00000463907
ENST00000469622
ENST00000489231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0009822 alkaloid catabolic process
GO:0010628 positive regulation of gene expression
GO:0042737 drug catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_13543
Xenobiotics pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.571258
RefSeq NM_000777 NM_001190484 NM_001291830
HUGO
OMIM
CCDS CCDS55134 CCDS5672
HPRD 05617
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca