InnateDB Protein
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IDBP-29639.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HERC6
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Protein Name
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hect domain and RLD 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369617
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InnateDB Gene
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IDBG-29637 (HERC6)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:15676274}.
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Disease Associations |
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Tissue Specificity |
Detected in brain, heart, placenta and testis. {ECO:0000269PubMed:15676274}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0042787
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protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR000408
Regulator of chromosome condensation, RCC1
IPR000569
HECT
IPR009091
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
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PFAM |
PF00415
PF00632
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PRINTS |
PR00633
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PIRSF |
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SMART |
SM00119
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IVU3
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PhosphoSite |
PhosphoSite-Q8IVU3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55008
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UniGene |
Hs.529317
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RefSeq |
NP_001158608
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HUGO |
HGNC:26072
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OMIM |
609249
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CCDS |
CCDS54777
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HPRD |
13647
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IMGT |
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EMBL |
AF336798
AK000644
AK092403
AK295832
AL833664
AY653201
BC035775
BC042047
BX647121
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GenPept |
AAH35775
AAH42047
AAQ14893
AAV66895
BAA91303
BAC03879
BAG58647
CAI46056
CAI46151
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