Version 5.4
Homo sapiens Protein: HERC6
Summary
InnateDB Protein IDBP-29643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC6
Protein Name hect domain and RLD 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264346
InnateDB Gene IDBG-29637 (HERC6)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:15676274}.
Disease Associations
Tissue Specificity Detected in brain, heart, placenta and testis. {ECO:0000269PubMed:15676274}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PF00632
PRINTS PR00633
PIRSF
SMART SM00119
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVU3
PhosphoSite PhosphoSite-Q8IVU3
TrEMBL B3KUG6
UniProt Splice Variant
Entrez Gene 55008
UniGene Hs.529317
RefSeq NP_060382
HUGO HGNC:26072
OMIM 609249
CCDS CCDS47098
HPRD 13647
IMGT
EMBL AF336798 AK000644 AK092403 AK097168 AK295832 AL833664 AY653201 BC035775 BC042047 BX647121
GenPept AAH35775 AAH42047 AAQ14893 AAV66895 BAA91303 BAC03879 BAG53428 BAG58647 CAI46056 CAI46151

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca