InnateDB Protein
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IDBP-29692.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AP3S2
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Protein Name
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adaptor-related protein complex 3, sigma 2 subunit
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Synonyms
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AP3S3; sigma3b;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000338777
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InnateDB Gene
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IDBG-29690 (AP3S2)
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Protein Structure
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Function |
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
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Subcellular Localization |
Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Present in all adult tissues examined. {ECO:0000269PubMed:9118953}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008565
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protein transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011012
Longin-like domain
IPR016635
Adaptor protein complex, sigma subunit
IPR022775
AP complex, mu/sigma subunit
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PFAM |
PF01217
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PRINTS |
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PIRSF |
PIRSF015588
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P59780
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PhosphoSite |
PhosphoSite-P59780
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TrEMBL |
A0A024RC62
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UniProt Splice Variant |
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Entrez Gene |
10239
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UniGene |
Hs.717481
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RefSeq |
NP_005820
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HUGO |
HGNC:571
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OMIM |
602416
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CCDS |
CCDS10357
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HPRD |
03880
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IMGT |
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EMBL |
AC018988
AC027176
AK222698
AK294712
AK312467
BC002785
BC010020
CH471101
X99459
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GenPept |
AAH02785
AAH10020
BAD96418
BAG35374
BAG57864
CAA67824
EAX02071
EAX02073
EAX02074
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