Version 5.4
Homo sapiens Protein: E2F6
Summary
InnateDB Protein IDBP-29757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F6
Protein Name E2F transcription factor 6
Synonyms E2F-6;
Species Homo sapiens
Ensembl Protein ENSP00000302159
InnateDB Gene IDBG-29751 (E2F6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
PFAM PF02319
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75461
PhosphoSite PhosphoSite-O75461
TrEMBL Q6Q9Z5
UniProt Splice Variant
Entrez Gene 1876
UniGene Hs.708518
RefSeq NP_001265204
HUGO HGNC:3120
OMIM 602944
CCDS CCDS62859
HPRD 04251
IMGT
EMBL AC099344 AF041381 AF059292 AJ493061 AK096197 AK290413 AY083996 AY083997 AY551347 AY551348 AY551349 AY551350 AY551351 BC008348 BC107740 CH471053
GenPept AAC14694 AAC31426 AAH08348 AAI07741 AAM10783 AAM10784 AAM10785 AAT02637 AAT02638 AAT02639 AAT02640 AAT02641 AAY14826 BAF83102 BAG53228 CAD37950 EAX00931 EAX00934 EAX00935 EAX00936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca