Version 5.4
Homo sapiens Protein: CRHBP
Summary
InnateDB Protein IDBP-29794.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRHBP
Protein Name corticotropin releasing hormone binding protein
Synonyms CRF-BP; CRFBP;
Species Homo sapiens
Ensembl Protein ENSP00000274368
InnateDB Gene IDBG-29790 (CRHBP)
Protein Structure
UniProt Annotation
Function Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042277 peptide binding
GO:0051424 corticotropin-releasing hormone binding
Biological Process
GO:0001963 synaptic transmission, dopaminergic
GO:0002125 maternal aggressive behavior
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007611 learning or memory
GO:0009755 hormone-mediated signaling pathway
GO:0033554 cellular response to stress
GO:0035690 cellular response to drug
GO:0035865 cellular response to potassium ion
GO:0042445 hormone metabolic process
GO:0045055 regulated secretory pathway
GO:0048149 behavioral response to ethanol
GO:0051459 regulation of corticotropin secretion
GO:0051460 negative regulation of corticotropin secretion
GO:0071277 cellular response to calcium ion
GO:0071314 cellular response to cocaine
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005767 secondary lysosome
GO:0005771 multivesicular body
GO:0005874 microtubule
GO:0030141 secretory granule
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0043196 varicosity
GO:0043204 perikaryon
GO:0043679 axon terminus
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR008435 Corticotropin-releasing factor binding
PFAM PF00431
PF05428
PRINTS
PIRSF PIRSF009279
SMART SM00042
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P24387
PhosphoSite PhosphoSite-P24387
TrEMBL
UniProt Splice Variant
Entrez Gene 1393
UniGene Hs.732643
RefSeq NP_001873
HUGO HGNC:2356
OMIM 122559
CCDS CCDS4034
HPRD 08348
IMGT
EMBL AK223457 BC018038 CH471084 CR541666 S60697 X58022
GenPept AAD13916 AAH18038 BAD97177 CAA41086 CAG46467 EAW95786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca