InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR9

Summary

InnateDB Protein

IDBP-29832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR9

Protein Name

chemokine (C-C motif) receptor 9

Synonyms

CC-CKR-9; CDw199; GPR-9-6; GPR28;

Species

Homo sapiens

Ensembl Protein

ENSP00000350256

InnateDB Gene

IDBG-29830 (CCR9)

Protein Structure

UniProt Annotation

Function

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the thymus and low in lymph nodes and spleen. {ECO:0000269PubMed:10229797, ECO:0000269PubMed:10640743}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR001718 CC chemokine receptor 7
IPR004069 CC chemokine receptor 9
IPR005383 CC chemokine receptor like 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS