InnateDB Protein
|
IDBP-29860.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
HERC3
|
Protein Name
|
hect domain and RLD 3
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000264345
|
InnateDB Gene
|
IDBG-29858 (HERC3)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
14
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0016567
|
protein ubiquitination
|
GO:0042787
|
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000408
Regulator of chromosome condensation, RCC1
IPR000569
HECT
IPR009091
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
|
PFAM |
PF00415
PF00632
|
PRINTS |
PR00633
|
PIRSF |
|
SMART |
SM00119
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q15034
|
PhosphoSite |
PhosphoSite-Q15034
|
TrEMBL |
Q4W5H5
|
UniProt Splice Variant |
|
Entrez Gene |
8916
|
UniGene |
Hs.734064
|
RefSeq |
XP_005263388
|
HUGO |
HGNC:4876
|
OMIM |
605200
|
CCDS |
CCDS34028
|
HPRD |
16093
|
IMGT |
|
EMBL |
AC083829
AC098582
AC108065
AK289990
AK296379
CH471057
D25215
|
GenPept |
AAY41038
BAA04945
BAF82679
BAG59053
EAX06024
|
|
|