Version 5.4
Homo sapiens Protein: GLP2R
Summary
InnateDB Protein IDBP-29887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLP2R
Protein Name glucagon-like peptide 2 receptor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262441
InnateDB Gene IDBG-29885 (GLP2R)
Protein Structure
UniProt Annotation
Function This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004967 glucagon receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR017981 GPCR, family 2-like
PFAM PF00002
PF02793
PRINTS PR00249
PIRSF
SMART SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95838
PhosphoSite PhosphoSite-O95838
TrEMBL I3L0P5
UniProt Splice Variant
Entrez Gene 9340
UniGene Hs.248202
RefSeq NP_004237
HUGO HGNC:4325
OMIM 603659
CCDS CCDS11150
HPRD 04713
IMGT
EMBL AC026591 AF105367 BC096262
GenPept AAD16895 AAH96262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca