InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLP2R

Summary

InnateDB Gene

IDBG-29885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLP2R

Gene Name

glucagon-like peptide 2 receptor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000065325

Encoded Proteins

IDBP-29887

glucagon-like peptide 2 receptor

IDBP-29889

glucagon-like peptide 2 receptor

IDBP-368242

glucagon-like peptide 2 receptor

IDBP-761964

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:9822206-9892102

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000262441	ENSP00000262441
ENST00000304773	ENSP00000303605
ENST00000458005	ENSP00000404471
ENST00000574745	ENSP00000458242

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004967	glucagon receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049928

View Gene Order

ENSBTAG00000005052

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18377

Glucagon-type ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.248202

RefSeq

NM_004246 XM_005256861

HUGO

OMIM

CCDS

CCDS11150

HPRD

04713

IMGT

EMBL

GenPept

RNA Seq Atlas