InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMARCD1

Summary

InnateDB Protein

IDBP-29962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCD1

Protein Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1

Synonyms

BAF60A; CRACD1; Rsc6p;

Species

Homo sapiens

Ensembl Protein

ENSP00000370924

InnateDB Gene

IDBG-32344 (SMARCD1)

Protein Structure

UniProt Annotation

Function

Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. {ECO:0000250, ECO:0000269PubMed:12837248, ECO:0000269PubMed:12917342, ECO:0000269PubMed:14698202, ECO:0000269PubMed:8804307}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8804307, ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. {ECO:0000269PubMed:8804307}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	100 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0048096	chromatin-mediated maintenance of transcription