Version 5.4
Homo sapiens Protein: ST8SIA5
Summary
InnateDB Protein IDBP-2997.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA5
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000321343
InnateDB Gene IDBG-2995 (ST8SIA5)
Protein Structure
UniProt Annotation
Function May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. {ECO:0000269PubMed:9199191}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in fetal and adult brain, adult heart and skeletal muscle. {ECO:0000269PubMed:9199191}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0097503 sialylation
Cellular Component
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15466
PhosphoSite PhosphoSite-O15466
TrEMBL B3KSU2
UniProt Splice Variant
Entrez Gene 29906
UniGene Hs.733140
RefSeq NP_037437
HUGO HGNC:17827
OMIM 607162
CCDS CCDS11930
HPRD 06199
IMGT
EMBL AK056270 AK094273 BC108910 BC108911 CH471088 CR457037 U91641
GenPept AAC51727 AAI08911 AAI08912 BAG51661 BAG52854 CAG33318 EAX01483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca