InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR3

Summary

InnateDB Protein

IDBP-30127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR3

Protein Name

chemokine (C-C motif) receptor 3

Synonyms

CC-CKR-3; CD193; CKR3; CMKBR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000350003

InnateDB Gene

IDBG-30125 (CCR3)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In eosinophils as well as trace amounts in neutrophils and monocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR002236 CC chemokine receptor 1
IPR002238 CC chemokine receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR01106
PR01108

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51677