Version 5.4
Homo sapiens Gene: CCR3
Summary
InnateDB Gene IDBG-30125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCR3
Gene Name chemokine (C-C motif) receptor 3
Synonyms CC-CKR-3; CD193; CKR3; CMKBR3
Species Homo sapiens
Ensembl Gene ENSG00000183625
Encoded Proteins
IDBP-30127
chemokine (C-C motif) receptor 3
IDBP-238545
chemokine (C-C motif) receptor 3
IDBP-238547
chemokine (C-C motif) receptor 3
IDBP-374477
chemokine (C-C motif) receptor 3
IDBP-374481
chemokine (C-C motif) receptor 3
IDBP-589957
chemokine (C-C motif) receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21660963
Epithelial CCR3 is involved in the progression of LPS-induced lung inflammation by mediating the release of IL8.
InnateDB Annotation from Orthologs
Summary
PMID 21660963
[Mus musculus] Epithelial Ccr3 is involved in the progression of LPS-induced lung inflammation by mediating the release of Il8.
Entrez Gene
Summary The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:46163604-46266706
Strand Forward strand
Band p21.31
Transcripts
ENST00000357422 ENSP00000350003
ENST00000395942 ENSP00000379273
ENST00000395940 ENSP00000379271
ENST00000452454 ENSP00000389336
ENST00000457243 ENSP00000401822
ENST00000484025
ENST00000475150
ENST00000545097 ENSP00000441600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 23 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0016032 viral process
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035448
View Gene Order
ENSBTAG00000001338
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.506190 Hs.730136
RefSeq NM_001164680 NM_001837 NM_178328 NM_178329 XM_006712960
HUGO
OMIM
CCDS CCDS2738 CCDS54574
HPRD 03167
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca