InnateDB Protein
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IDBP-30246.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CPB2
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Protein Name
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carboxypeptidase B2 (plasma)
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Synonyms
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CPU; PCPB; TAFI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000181383
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InnateDB Gene
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IDBG-30244 (CPB2)
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Protein Structure
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Function |
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269PubMed:10574983}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Plasma; synthesized in the liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
7
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
IPR003146
Proteinase inhibitor, carboxypeptidase propeptide
IPR009020
Proteinase inhibitor, propeptide
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PFAM |
PF00246
PF02244
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PRINTS |
PR00765
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PIRSF |
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SMART |
SM00631
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TIGRFAMs |
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Modification |
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SwissProt |
Q96IY4
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PhosphoSite |
PhosphoSite-Q96IY4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1361
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UniGene |
Hs.512937
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RefSeq |
NP_001863
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HUGO |
HGNC:2300
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OMIM |
603101
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CCDS |
CCDS9401
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HPRD |
04374
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IMGT |
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EMBL |
AB011969
AK290829
AL137141
AL157758
AY714780
BC007057
BT006936
M75106
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GenPept |
AAA60042
AAH07057
AAP35582
AAT97987
BAA90475
BAF83518
CAI10904
CAI10905
CAI12170
CAI12171
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