InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CPB2

Summary

InnateDB Gene

IDBG-30244.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPB2

Gene Name

carboxypeptidase B2 (plasma)

Synonyms

CPU; PCPB; TAFI

Species

Homo sapiens

Ensembl Gene

ENSG00000080618

Encoded Proteins

IDBP-30246

carboxypeptidase B2 (plasma)

IDBP-367272

carboxypeptidase B2 (plasma)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. [provided by RefSeq, Apr 2012]
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:46053186-46105076

Strand

Reverse strand

Band

q14.13

Transcripts

ENST00000181383	ENSP00000181383
ENST00000439329	ENSP00000400714

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0003331	positive regulation of extracellular matrix constituent secretion
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0009408	response to heat
GO:0010757	negative regulation of plasminogen activation
GO:0042493	response to drug
GO:0042730	fibrinolysis
GO:0051918	negative regulation of fibrinolysis
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration
GO:2000346	negative regulation of hepatocyte proliferation

Cellular Component

GO:0005615

extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021999

View Gene Order

ENSBTAG00000007073

Not yet available

Pathways

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

hsa04972

Pancreatic secretion pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q96IY4

TrEMBL

UniProt Splice Variant

Entrez Gene

1361

UniGene

Hs.512937

RefSeq

NM_001278541 NM_001872 XM_005266257 XM_005266258

HUGO

HGNC:2300

OMIM

603101

CCDS

CCDS73568 CCDS9401

HPRD

IMGT

EMBL

AB011969 AK290829 AL137141 AL157758 AY714780 BC007057 BT006936 M75106

GenPept

AAA60042 AAH07057 AAP35582 AAT97987 BAA90475 BAF83518 CAI10904 CAI10905 CAI12170 CAI12171

RNA Seq Atlas

1361