InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH4

Summary

InnateDB Protein

IDBP-30265.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH4

Protein Name

myosin, heavy chain 4, skeletal muscle

Synonyms

MYH2B; MyHC-2B; MyHC-IIb;

Species

Homo sapiens

Ensembl Protein

ENSP00000255381

InnateDB Gene

IDBG-729182 (MYH4)

Protein Structure

UniProt Annotation

Function

Muscle contraction.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003725	double-stranded RNA binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008307	structural constituent of muscle

Biological Process

GO:0006200	ATP catabolic process
GO:0006936	muscle contraction
GO:0014823	response to activity
GO:0030048	actin filament-based movement
GO:0030049	muscle filament sliding
GO:0061024	membrane organization

Cellular Component

GO:0005737	cytoplasm
GO:0005859	muscle myosin complex
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0032982	myosin filament

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt