InnateDB Protein
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IDBP-30417.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCRL2
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Protein Name
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chemokine (C-C motif) receptor-like 2
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Synonyms
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ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349967
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InnateDB Gene
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IDBG-30415 (CCRL2)
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Protein Structure
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Function |
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:18397265, ECO:0000269PubMed:20002784}; Multi-pass membrane protein {ECO:0000269PubMed:18397265, ECO:0000269PubMed:20002784}.
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Disease Associations |
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Tissue Specificity |
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269PubMed:11828366, ECO:0000269PubMed:15188357, ECO:0000269PubMed:18397265, ECO:0000269PubMed:9473515}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR000355
Chemokine receptor family
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
PR00657
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O00421
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PhosphoSite |
PhosphoSite-O00421
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TrEMBL |
C9JP23
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UniProt Splice Variant |
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Entrez Gene |
9034
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UniGene |
Hs.535713
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RefSeq |
NP_001124382
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HUGO |
HGNC:1612
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OMIM |
608379
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CCDS |
CCDS46814
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HPRD |
16327
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IMGT |
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EMBL |
AC098613
AF014958
AF015524
AF015525
AJ344142
AK296673
AK313312
AY337001
BC025717
BC071682
BC096075
BC096076
BC099623
CH471055
U95626
U97123
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GenPept |
AAB57794
AAB82106
AAC34601
AAC34602
AAC39595
AAH25717
AAH71682
AAH96075
AAH96076
AAH99623
AAQ76789
BAG36117
BAG59270
CAC82985
EAW64765
EAW64766
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