InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNB3

Summary

InnateDB Protein

IDBP-30420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNB3

Protein Name

calcium channel, voltage-dependent, beta 3 subunit

Synonyms

CAB3; CACNLB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000301050

InnateDB Gene

IDBG-30418 (CACNB3)

Protein Structure

UniProt Annotation

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed mostly in brain, smooth muscle and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0034765	regulation of ion transmembrane transport
GO:0050852	T cell receptor signaling pathway
GO:0051899	membrane depolarization
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005829	cytosol
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunit
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF12052
PF00018
PF14604
PF00625

PRINTS

PR01626
PR00452
PR01696

PIRSF

SMART

SM00326
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt