Version 5.4
Homo sapiens Gene: CACNB3
Summary
InnateDB Gene IDBG-30418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNB3
Gene Name calcium channel, voltage-dependent, beta 3 subunit
Synonyms CAB3; CACNLB3
Species Homo sapiens
Ensembl Gene ENSG00000167535
Encoded Proteins
IDBP-30420
calcium channel, voltage-dependent, beta 3 subunit
IDBP-590696
calcium channel, voltage-dependent, beta 3 subunit
IDBP-584886
calcium channel, voltage-dependent, beta 3 subunit
IDBP-601718
calcium channel, voltage-dependent, beta 3 subunit
IDBP-595926
calcium channel, voltage-dependent, beta 3 subunit
IDBP-586943
calcium channel, voltage-dependent, beta 3 subunit
IDBP-586485
calcium channel, voltage-dependent, beta 3 subunit
IDBP-595825
calcium channel, voltage-dependent, beta 3 subunit
IDBP-590634
calcium channel, voltage-dependent, beta 3 subunit
IDBP-592787
calcium channel, voltage-dependent, beta 3 subunit
IDBP-586560
calcium channel, voltage-dependent, beta 3 subunit
IDBP-584139
calcium channel, voltage-dependent, beta 3 subunit
IDBP-603101
calcium channel, voltage-dependent, beta 3 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:48813794-48828941
Strand Forward strand
Band q13.12
Transcripts
ENST00000301050 ENSP00000301050
ENST00000552480
ENST00000548279 ENSP00000449497
ENST00000550771
ENST00000547230 ENSP00000448304
ENST00000551544 ENSP00000447462
ENST00000552812
ENST00000550190 ENSP00000447261
ENST00000550483 ENSP00000448076
ENST00000547392 ENSP00000446529
ENST00000547818 ENSP00000448137
ENST00000550064 ENSP00000448074
ENST00000552022
ENST00000549971
ENST00000552465
ENST00000550168
ENST00000551716
ENST00000540990 ENSP00000445495
ENST00000549226
ENST00000548860
ENST00000536187 ENSP00000444160
ENST00000548874 ENSP00000446611
ENST00000550391 ENSP00000449389
ENST00000547693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0034765 regulation of ion transmembrane transport
GO:0050852 T cell receptor signaling pathway
GO:0051899 membrane depolarization
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005829 cytosol
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003352
View Gene Order
ENSBTAG00000021808
Not yet available
Pathways
NETPATH
REACTOME
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.250712 Hs.587729
RefSeq NM_000725 NM_001206915 NM_001206916 NM_001206917 XM_005269142
HUGO
OMIM
CCDS CCDS55821 CCDS55822 CCDS55823 CCDS8769
HPRD 11879
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca