InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH2

Summary

InnateDB Protein

IDBP-30435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH2

Protein Name

myosin, heavy chain 2, skeletal muscle, adult

Synonyms

IBM3; MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000245503

InnateDB Gene

IDBG-30433 (MYH2)

Protein Structure

UniProt Annotation

Function

Muscle contraction. Required for cytoskeleton organization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Inclusion body myopathy 3 (IBM3) [MIM:605637]: Hereditary inclusion body myopathies constitute a group of neuromuscular disorders characterized by slowly progressive distal and proximal weakness and a typical muscle pathology including rimmed vacuoles and filamentous inclusions. IBM3 is a variant of hereditary inclusion body myopathies and is characterized by autosomal dominant myopathy with joint contracture, ophthalmoplegia and rimmed vacuoles. Morphological analysis of muscle biopsies from patients indicate that the type 2A fibers frequently were abnormal, whereas other fiber types appeared normal. {ECO:0000269PubMed:11114175}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003735	structural constituent of ribosome
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0001778	plasma membrane repair
GO:0006412	translation
GO:0006936	muscle contraction
GO:0008152	metabolic process
GO:0014823	response to activity
GO:0016192	vesicle-mediated transport
GO:0030049	muscle filament sliding
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0061024	membrane organization
GO:0070252	actin-mediated cell contraction

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005826	actomyosin contractile ring
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005859	muscle myosin complex
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0031672	A band
GO:0032982	myosin filament
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR001854 Ribosomal protein L29
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR010989 t-SNARE
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF00831
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt