InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX23

Summary

InnateDB Protein

IDBP-30455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX23

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Synonyms

prp28; PRPF28; SNRNP100; U5-100K; U5-100KD;

Species

Homo sapiens

Ensembl Protein

ENSP00000310723

InnateDB Gene

IDBG-30453 (DDX23)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. {ECO:0000269PubMed:18425142}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20858735, ECO:0000269PubMed:9409622}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000354	cis assembly of pre-catalytic spliceosome
GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005682	U5 snRNP
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BUQ8