InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDLIM5

Summary

InnateDB Protein

IDBP-30479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDLIM5

Protein Name

PDZ and LIM domain 5

Synonyms

ENH; ENH1; LIM;

Species

Homo sapiens

Ensembl Protein

ENSP00000321746

InnateDB Gene

IDBG-30475 (PDLIM5)

Protein Structure

UniProt Annotation

Function

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected both at presynaptic and postsynaptic sites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. {ECO:0000269PubMed:10429367, ECO:0000269PubMed:16044170, ECO:0000269PubMed:16213469}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042805	actinin binding

Biological Process

GO:0051963	regulation of synapse assembly
GO:0061001	regulation of dendritic spine morphogenesis

Cellular Component

GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane