Version 5.4
Homo sapiens Gene: PDLIM5
Summary
InnateDB Gene IDBG-30475.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM5
Gene Name PDZ and LIM domain 5
Synonyms ENH; ENH1; LIM
Species Homo sapiens
Ensembl Gene ENSG00000163110
Encoded Proteins
IDBP-30477
PDZ and LIM domain 5
IDBP-30479
PDZ and LIM domain 5
IDBP-30483
PDZ and LIM domain 5
IDBP-30485
PDZ and LIM domain 5
IDBP-374560
PDZ and LIM domain 5
IDBP-473393
PDZ and LIM domain 5
IDBP-476095
PDZ and LIM domain 5
IDBP-473846
PDZ and LIM domain 5
IDBP-475722
PDZ and LIM domain 5
IDBP-485081
PDZ and LIM domain 5
IDBP-479483
PDZ and LIM domain 5
IDBP-479621
PDZ and LIM domain 5
IDBP-477296
PDZ and LIM domain 5
IDBP-604029
PDZ and LIM domain 5
IDBP-808536
PDZ and LIM domain 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:94451857-94668227
Strand Forward strand
Band q22.3
Transcripts
ENST00000359265 ENSP00000352210
ENST00000317968 ENSP00000321746
ENST00000380180 ENSP00000369527
ENST00000318007 ENSP00000322021
ENST00000380176
ENST00000437932 ENSP00000398469
ENST00000514830
ENST00000512274 ENSP00000426379
ENST00000509333
ENST00000503974 ENSP00000424297
ENST00000504489 ENSP00000423009
ENST00000508216 ENSP00000426804
ENST00000514743 ENSP00000424360
ENST00000511767
ENST00000510099
ENST00000509357 ENSP00000422833
ENST00000513341 ENSP00000429577
ENST00000508531
ENST00000511586
ENST00000506632 ENSP00000422528
ENST00000542407 ENSP00000442187
ENST00000615540 ENSP00000480359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042805 actinin binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0051963 regulation of synapse assembly
GO:0061001 regulation of dendritic spine morphogenesis
Cellular Component
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030018 Z disc
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028273
View Gene Order
ENSBTAG00000012818
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001011513 NM_001011515 NM_001011516 NM_001256425 NM_001256426 NM_001256427 NM_001256428 NM_001256429 NM_006457 XM_005262693 XM_005262695 XM_005262696 XM_005262698 XM_006714066 XM_006714067 XM_006714068 XM_006714069 XM_006714070
HUGO
OMIM
CCDS CCDS3641 CCDS47103 CCDS47104 CCDS58915 CCDS58916 CCDS58917 CCDS75166
HPRD 05799
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca