InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKD1

Summary

InnateDB Protein

IDBP-30582.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKD1

Protein Name

naked cuticle homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268459

InnateDB Gene

IDBG-30580 (NKD1)

Protein Structure

UniProt Annotation

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269PubMed:11752446, ECO:0000269PubMed:15687260, ECO:0000269PubMed:16567647}.

Subcellular Localization

Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. {ECO:0000269PubMed:11604995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001754	eye photoreceptor cell differentiation
GO:0007525	somatic muscle development
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0045732	positive regulation of protein catabolic process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090249	regulation of cell motility involved in somitogenic axis elongation
GO:1901231	positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade
GO:1901233	negative regulation of convergent extension involved in axis elongation
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway