Version 5.4
Homo sapiens Gene: NKD1
Summary
InnateDB Gene IDBG-30580.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKD1
Gene Name naked cuticle homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140807
Encoded Proteins
IDBP-30582
naked cuticle homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:50548330-50640739
Strand Forward strand
Band q12.1
Transcripts
ENST00000268459 ENSP00000268459
ENST00000566396
ENST00000564336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0001754 eye photoreceptor cell differentiation
GO:0007525 somatic muscle development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045732 positive regulation of protein catabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090249 regulation of cell motility involved in somitogenic axis elongation
GO:1901231 positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade
GO:1901233 negative regulation of convergent extension involved in axis elongation
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031661
View Gene Order
ENSBTAG00000012295
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q969G9
TrEMBL
UniProt Splice Variant
Entrez Gene 85407
UniGene Hs.187578 Hs.298434 Hs.608915
RefSeq NM_033119 XM_005256211
HUGO HGNC:17045
OMIM 607851
CCDS CCDS10743
HPRD
IMGT
EMBL AB062886 AF289584 AF358135 AK314930 AY061883 BC051288 CH471092
GenPept AAH51288 AAK57484 AAL32374 AAL55768 BAB70500 BAG37436 EAW82761
RNA Seq Atlas 85407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca