InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPAG1

Summary

InnateDB Protein

IDBP-30600.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPAG1

Protein Name

sperm associated antigen 1

Synonyms

CILD28; CT140; HSD-3.8; SP75; TPIS;

Species

Homo sapiens

Ensembl Protein

ENSP00000373450

InnateDB Gene

IDBG-30594 (SPAG1)

Protein Structure

UniProt Annotation

Function

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269PubMed:11517287, ECO:0000269PubMed:1299558}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11517287, ECO:0000269PubMed:16983343}. Note=Colocalizes with tubulin.

Disease Associations

Ciliary dyskinesia, primary, 28 (CILD28) [MIM:615505]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. {ECO:0000269PubMed:11517287, ECO:0000269PubMed:1299558, ECO:0000269PubMed:16983343, ECO:0000269PubMed:24055112}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016787	hydrolase activity

Biological Process

GO:0007338	single fertilization
GO:0008152	metabolic process
GO:0070286	axonemal dynein complex assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q07617