Version 5.4
Homo sapiens Protein: WNT10B
Summary
InnateDB Protein IDBP-30682.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT10B
Protein Name wingless-type MMTV integration site family, member 10B
Synonyms SHFM6; WNT-12;
Species Homo sapiens
Ensembl Protein ENSP00000301061
InnateDB Gene IDBG-30678 (WNT10B)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269PubMed:18515319}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0048018 receptor agonist activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0007050 cell cycle arrest
GO:0007224 smoothened signaling pathway
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030858 positive regulation of epithelial cell differentiation
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043403 skeletal muscle tissue regeneration
GO:0045165 cell fate commitment
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048641 regulation of skeletal muscle tissue development
GO:0048741 skeletal muscle fiber development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0050909 sensory perception of taste
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051246 regulation of protein metabolic process
GO:0051885 positive regulation of anagen
GO:0060070 canonical Wnt signaling pathway
GO:0060346 bone trabecula formation
GO:0061196 fungiform papilla development
GO:0071300 cellular response to retinoic acid
GO:0071310 cellular response to organic substance
GO:0071320 cellular response to cAMP
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071425 hematopoietic stem cell proliferation
GO:0071464 cellular response to hydrostatic pressure
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
IPR013302 Wnt-10 protein
PFAM PF00110
PRINTS PR01349
PR01893
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00744
PhosphoSite PhosphoSite-O00744
TrEMBL C9JCI2
UniProt Splice Variant
Entrez Gene 7480
UniGene Hs.91985
RefSeq NP_003385
HUGO HGNC:12775
OMIM 601906
CCDS CCDS8775
HPRD 03548
IMGT
EMBL AB070724 AC073610 AF028700 AK312906 BC096353 BC096354 BC096356 CH471111 U81787 X97057
GenPept AAB51685 AAC39549 AAH96353 AAH96354 AAH96356 BAB72181 BAG35752 CAA65769 EAW58028

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca