InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF6

Summary

InnateDB Protein

IDBP-30685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6

Protein Name

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa

Synonyms

MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85;

Species

Homo sapiens

Ensembl Protein

ENSP00000344537

InnateDB Gene

IDBG-30683 (TAF6)

Protein Structure

UniProt Annotation

Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	70 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0016032	viral process
GO:0045786	negative regulation of cell cycle
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0033276	transcription factor TFTC complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR004823 TATA box binding protein associated factor (TAF)
IPR009072 Histone-fold
IPR011442 Domain of unknown function DUF1546
IPR016024 Armadillo-type fold

PFAM

PF02969
PF07571

PRINTS

PIRSF

SMART

SM00803

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49848