InnateDB Protein
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IDBP-30823.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GAL3ST4
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Protein Name
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galactose-3-O-sulfotransferase 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353142
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InnateDB Gene
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IDBG-30821 (GAL3ST4)
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Protein Structure
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Function |
Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc. {ECO:0000269PubMed:11333265}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node. {ECO:0000269PubMed:11333265}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001733
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galactosylceramide sulfotransferase activity
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GO:0050656
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3'-phosphoadenosine 5'-phosphosulfate binding
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GO:0050694
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galactose 3-O-sulfotransferase activity
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GO:0050698
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proteoglycan sulfotransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009729
Galactose-3-O-sulfotransferase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF06990
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96RP7
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PhosphoSite |
PhosphoSite-Q96RP7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79690
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UniGene |
Hs.44856
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RefSeq |
NP_078913
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HUGO |
HGNC:24145
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OMIM |
608235
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CCDS |
CCDS5688
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HPRD |
12195
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IMGT |
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EMBL |
AF289575
AF316113
AK022178
AL833824
BC012976
CH236956
CH471091
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GenPept |
AAH12976
AAK73365
AAL55759
BAB13977
CAD38686
EAL23847
EAW76575
EAW76577
EAW76579
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