InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASNA1

Summary

InnateDB Protein

IDBP-30882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASNA1

Protein Name

arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Synonyms

ARSA-I; ARSA1; ASNA-I; GET3; hASNA-I; TRC40;

Species

Homo sapiens

Ensembl Protein

ENSP00000349887

InnateDB Gene

IDBG-30880 (ASNA1)

Protein Structure

UniProt Annotation

Function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. {ECO:0000255HAMAP-Rule:MF_03112, ECO:0000269PubMed:17382883, ECO:0000269PubMed:18477612}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. {ECO:0000269PubMed:9774623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0015105	arsenite transmembrane transporter activity
GO:0016887	ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015698	inorganic anion transport
GO:0045048	protein insertion into ER membrane

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR016300 Arsenical pump ATPase, ArsA/GET3
IPR025723 Anion-transporting ATPase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01656
PF02374

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43681

PhosphoSite