Version 5.4
Homo sapiens Gene: ASNA1
Summary
InnateDB Gene IDBG-30880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASNA1
Gene Name arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Synonyms ARSA-I; ARSA1; ASNA-I; GET3; hASNA-I; TRC40
Species Homo sapiens
Ensembl Gene ENSG00000198356
Encoded Proteins
IDBP-30882
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
IDBP-761418
IDBP-764290
IDBP-813385
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12737139-12748323
Strand Forward strand
Band p13.13
Transcripts
ENST00000357332 ENSP00000349887
ENST00000590633
ENST00000586561 ENSP00000468450
ENST00000591090 ENSP00000466379
ENST00000611688 ENSP00000481254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0015105 arsenite transmembrane transporter activity
GO:0016887 ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0015698 inorganic anion transport
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052456
View Gene Order
ENSBTAG00000011837
Not yet available
Cross-References
SwissProt O43681
TrEMBL K7ERW9
UniProt Splice Variant
Entrez Gene 439
UniGene Hs.602674
RefSeq NM_004317
HUGO HGNC:752
OMIM 601913
CCDS CCDS32920
HPRD
IMGT
EMBL AC018761 AF047469 AK223363 AK291855 AY304483 BC002651 CH471106 U60276
GenPept AAC03551 AAC50731 AAH02651 AAP45050 BAD97083 BAF84544 EAW84303
RNA Seq Atlas 439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca