InnateDB Protein
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IDBP-30898.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STAG3
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Protein Name
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stromal antigen 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000319318
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InnateDB Gene
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IDBG-30896 (STAG3)
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Protein Structure
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Function |
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00750, ECO:0000269PubMed:12034751}. Chromosome {ECO:0000269PubMed:12034751}. Chromosome, centromere {ECO:0000269PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation.
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Disease Associations |
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Tissue Specificity |
Testis specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013721
STAG
IPR016024
Armadillo-type fold
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PFAM |
PF08514
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UJ98
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PhosphoSite |
PhosphoSite-Q9UJ98
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TrEMBL |
C9JYW5
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UniProt Splice Variant |
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Entrez Gene |
10734
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UniGene |
Hs.592283
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RefSeq |
NP_036579
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HUGO |
HGNC:11356
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OMIM |
608489
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CCDS |
CCDS34703
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HPRD |
10253
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IMGT |
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EMBL |
AC005071
AC073842
AJ007798
AK302587
AK302693
AL833816
BC146806
CH471091
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GenPept |
AAI46807
BAG63840
BAG63922
CAB59367
CAD38679
EAW76568
EAW76570
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