Version 5.4
Homo sapiens Gene: STAG3
Summary
InnateDB Gene IDBG-30896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAG3
Gene Name stromal antigen 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000066923
Encoded Proteins
IDBP-30898
stromal antigen 3
IDBP-242439
stromal antigen 3
IDBP-383363
stromal antigen 3
IDBP-383367
stromal antigen 3
IDBP-383371
stromal antigen 3
IDBP-383372
stromal antigen 3
IDBP-383375
stromal antigen 3
IDBP-383377
stromal antigen 3
IDBP-813059
stromal antigen 3
IDBP-813060
stromal antigen 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100177563-100221488
Strand Forward strand
Band q22.1
Transcripts
ENST00000317296 ENSP00000319318
ENST00000394018 ENSP00000377586
ENST00000426455 ENSP00000400359
ENST00000416412 ENSP00000409283
ENST00000422690 ENSP00000407884
ENST00000439782 ENSP00000397067
ENST00000412190 ENSP00000395039
ENST00000451963 ENSP00000393790
ENST00000440830
ENST00000496157
ENST00000482546
ENST00000459699
ENST00000491498
ENST00000477469
ENST00000476057
ENST00000479359
ENST00000492674
ENST00000620100 ENSP00000484098
ENST00000615138 ENSP00000477973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007130 synaptonemal complex assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0000800 lateral element
GO:0000802 transverse filament
GO:0001673 male germ cell nucleus
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030893 meiotic cohesin complex
GO:0034991 nuclear meiotic cohesin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036928
View Gene Order
ENSBTAG00000010496
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JTG4 C9JYW5
UniProt Splice Variant
Entrez Gene 10734
UniGene Hs.592283
RefSeq NM_001282716 NM_001282717 NM_001282718 NM_012447 XM_005250116
HUGO HGNC:11356
OMIM 608489
CCDS CCDS34703 CCDS64730 CCDS75642
HPRD 10253
IMGT
EMBL AC005071 AC073842
GenPept
RNA Seq Atlas 10734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca