Version 5.4
Homo sapiens Protein: HOOK2
Summary
InnateDB Protein IDBP-30952.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK2
Protein Name hook homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264827
InnateDB Gene IDBG-30950 (HOOK2)
Protein Structure
UniProt Annotation
Function Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269PubMed:17140400, ECO:0000269PubMed:17540036, ECO:0000269PubMed:18799622}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 36 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005813 centrosome
GO:0005874 microtubule
GO:0030897 HOPS complex
GO:0070695 FHF complex
Protein Structure and Domains
PDB ID
InterPro IPR008636 Hook-related protein family
PFAM PF05622
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96ED9
PhosphoSite PhosphoSite-Q96ED9
TrEMBL K7ENU5
UniProt Splice Variant
Entrez Gene 29911
UniGene Hs.30792
RefSeq NP_001093646
HUGO HGNC:19885
OMIM 607824
CCDS CCDS42507
HPRD 09698
IMGT
EMBL AC018761 AC020934 AF044924 BC012443
GenPept AAC09299 AAH12443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca