InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBL2

Summary

InnateDB Protein

IDBP-30967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBL2

Protein Name

retinoblastoma-like 2 (p130)

Synonyms

P130; Rb2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262133

InnateDB Gene

IDBG-30965 (RBL2)

Protein Structure

UniProt Annotation

Function

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 344 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	347 [view]
Protein-Protein	89 [view]
Protein-DNA	257 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0016568	chromatin modification
GO:0043550	regulation of lipid kinase activity
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002719 Retinoblastoma-associated protein, B-box
IPR002720 Retinoblastoma-associated protein, A-box
IPR013763 Cyclin-like
IPR024599 Retinoblastoma-associated protein, N-terminal

PFAM

PF01857
PF01858
PF11934

PRINTS

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08999